The model used in this paper confirmed the experimental findings suggesting that axonal Kv7 channels are critically and uniquely required for determining the inherent spontaneous firing of hippocampal CA1 pyramids, independently of alterations in synaptic activity. The model predicts that the axonal Kv7 density could be 3-5 times that at the soma.
Model Type: Neuron or other electrically excitable cell; Axon; Channel/Receptor
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I T low threshold; I A; I K; I M; I Calcium
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models; Axonal Action Potentials; Action Potentials
Simulation Environment: NEURON
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]
Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA. (2008). Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]