CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)

The model used in this paper confirmed the experimental findings suggesting that axonal Kv7 channels are critically and uniquely required for determining the inherent spontaneous firing of hippocampal CA1 pyramids, independently of alterations in synaptic activity. The model predicts that the axonal Kv7 density could be 3-5 times that at the soma.

Model Type: Neuron or other electrically excitable cell; Axon; Channel/Receptor

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I T low threshold; I A; I K; I M; I Calcium

Model Concept(s): Action Potential Initiation; Detailed Neuronal Models; Axonal Action Potentials; Action Potentials

Simulation Environment: NEURON

Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]

References:

Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA. (2008). Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]