O-LM interneuron model (Lawrence et al. 2006)

Exploring the kinetics and distribution of the muscarinic potassium channel, IM, in 2 O-LM interneuron morphologies. Modulation of the ion channel by drugs such as XE991 (antagonist) and retigabine (agonist) are simulated in the models to examine the role of IM in spiking properties.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hippocampus CA1 interneuron oriens alveus GABA cell

Currents: I L high threshold; I N; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca

Receptors: Muscarinic

Model Concept(s): Ion Channel Kinetics; Oscillations; Detailed Neuronal Models; Action Potentials

Simulation Environment: NEURON


Lawrence JJ et al. (2006). Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.