Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model (Humphries et al., 2021)

This model was used to compare the nonlinearity of NMDA inputs between dendritic sections in a CA3 pyramidal neuron as well as investigate the effect of cholinergic modulation/potassium channel inhibition on this dendritic NMDA-mediated nonlinearity.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA3 pyramidal GLU cell

Currents: I Potassium

Receptors: NMDA; AMPA

Transmitters: Acetylcholine

Model Concept(s): Active Dendrites; Dendritic Action Potentials; Detailed Neuronal Models; Neuromodulation

Simulation Environment: NEURON; Python

Implementer(s): Humphries, Rachel

References:

Humphries R, Mellor JR, O'Donnell C. (2022). Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model Neuroscience. 489 [PubMed]