This detailed microcircuit model explores the network level effects of sublayer specific connectivity in the mouse CA1. The differences in strengths and numbers of synapses between PV+ basket cells and either superficial sublayer or deep sublayer pyramidal cells enables a routing of inhibition from superficial to deep pyramidal cells. At the network level of this model, the effects become quite prominent when one compares the effect on firing rates when either the deep or superficial pyramidal cells receive a selective increase in excitation.
Model Type: Realistic Network
Region(s) or Organism(s): Hippocampus
Simulation Environment: NEURON
Implementer(s): Bezaire, Marianne [mariannejcase at gmail.com]