" ... We hypothesized that if two excitatory pathways bias their synaptic projections towards proximal vs. distal ends of the basal branches, the very different local spike thresholds and attenuation factors for inputs near and far from the soma might provide the basis for a classical-contextual functional asymmetry. Supporting this possibility, we found both in compartmental models and electrophysiological recordings in brain slices that the responses of basal dendrites to spatially separated inputs are indeed strongly asymmetric. ..."
Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite
Cell Type(s): Neocortex L5/6 pyramidal GLU cell
Currents: I Sodium; I Potassium
Transmitters: Glutamate
Model Concept(s): Dendritic Action Potentials; Spatio-temporal Activity Patterns; Active Dendrites; Detailed Neuronal Models; Synaptic Integration
Simulation Environment: NEURON; Python
Implementer(s): Behabadi, Bardia [bardiafb+mdb at gmail.com]
References:
Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW. (2012). Location-dependent excitatory synaptic interactions in pyramidal neuron dendrites. PLoS computational biology. 8 [PubMed]