Human Cortical L5 Pyramidal Cell (Rich et al. 2021)

This paper presents a full spiking, biophysically detailed multi-compartment model of a human cortical layer 5 (L5) pyramidal cell, where model development was primarily based on morphological and electrophysiological data from the same neuron. Focus was placed on capturing distinctly human dynamics of the h-channel and led to the articulation of a novel model of this channel's dynamics in humans. This led to an explanation for the surprising lack of subthreshold resonance seen in these cells in the human as opposed to rodent setting.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex layer 5 pyramidal cell; Hodgkin-Huxley neuron

Currents: I h; I M; I Na,p; I Na,t; I K; I Calcium

Model Concept(s): Active Dendrites; Detailed Neuronal Models

Simulation Environment: NEURON

Implementer(s): Rich, Scott [sbrich at]


Rich S, Moradi Chameh H, Sekulic V, Valiante TA, Skinner FK. (2021). Modeling Reveals Human-Rodent Differences in H-Current Kinetics Influencing Resonance in Cortical Layer 5 Neurons. Cerebral cortex (New York, N.Y. : 1991). 31 [PubMed]

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