CA3 pyramidal neuron (Lazarewicz et al 2002)

The model shows how using a CA1-like distribution of active dendritic conductances in a CA3 morphology results in dendritic initiation of spikes during a burst.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hippocampus CA3 pyramidal GLU cell

Currents: I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I CAN; I Calcium

Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Bursting; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials

Simulation Environment: NEURON

Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]; Lazarewicz, Maciej [mlazarew at gmu.edu]

References:

Lazarewicz MT, Migliore M, Ascoli GA. (2002). A new bursting model of CA3 pyramidal cell physiology suggests multiple locations for spike initiation. Bio Systems. 67 [PubMed]