Voltage attenuation in the apical dendritic field of CA1 pyramidal neurons is particularly strong for epsps spreading toward the soma. High cytoplasmic resistivity and high membrane (leak) conductance appear to be the major determinants of voltage attenuation over most of the apical field, but H current may be responsible for as much as half of the attenuation of distal apical epsps.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I h
Simulation Environment: NEURON (web link to model)
Implementer(s): Spruston, Nelson [Spruston at Northwestern.edu]; Golding, Nace L [golding at mail.utexas.edu]; Kath, William L [kath at northwestern.edu]; Mickus, Timothy ; Katz, Yael [y-katz at northwestern.edu]
Golding NL, Mickus TJ, Katz Y, Kath WL, Spruston N. (2005). Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites. The Journal of physiology. 568 [PubMed]