A multi-compartment model for interneurons in the dLGN (Halnes et al. 2011)

This model for dLGN interneurons is presented in two parameterizations (P1 & P2), which were fitted to current-clamp data from two different interneurons (IN1 & IN2). The model qualitatively reproduces the responses in IN1 & IN2 under 8 different experimental condition, and quantitatively reproduces the I/O-relations (#spikes elicited as a function of injected current).

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Thalamus lateral geniculate nucleus interneuron

Currents: I L high threshold; I T low threshold; I CAN; I Sodium; I Mixed; I Potassium; I_AHP

Model Concept(s): Activity Patterns; Active Dendrites; Detailed Neuronal Models; Rebound firing

Simulation Environment: NEURON

Implementer(s): Halnes, Geir [geir.halnes at nmbu.no]

References:

Halnes G, Augustinaite S, Heggelund P, Einevoll GT, Migliore M. (2011). A multi-compartment model for interneurons in the dorsal lateral geniculate nucleus. PLoS computational biology. 7 [PubMed]