NEURON files from the paper: A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. by M. Migliore, I. De Blasi, D. Tegolo, R. Migliore, Neural Networks,(2011), doi:10.1016/j.neunet.2011.01.001. Starting from the experimentally supported assumption on hippocampal neurons we explore an experimentally testable prediction at the single neuron level. The model shows how and to what extent a pathological hypofunction of a contextdependent distal input on a CA1 neuron can generate hallucinations by altering the normal recall of objects on which the neuron has been previously tuned. The results suggest that a change in the context during the recall phase may cause an occasional but very significant change in the set of active dendrites used for features recognition, leading to a distorted perception of objects.
Model Type: Dendrite
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I A; I K; I h; I Potassium
Receptors: AMPA
Transmitters: Glutamate
Model Concept(s): Dendritic Action Potentials; Coincidence Detection; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Schizophrenia; Hallucinations
Simulation Environment: NEURON
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]
References:
Migliore M, De Blasi I, Tegolo D, Migliore R. (2011). A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. Neural networks : the official journal of the International Neural Network Society. 24 [PubMed]