A set of 9 multi-compartmental rat GP neuron models (585 compartments) differing only in their expression of dendritic fast sodium channels were compared in their synaptic integration properties. Dendritic fast sodium channels were found to increase the importance of distal synapses (both excitatory AND inhibitory), increase spike timing variability with in vivo-like synaptic input, and make the model neurons highly sensitive to clustered synchronous excitation.
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Globus pallidus neuron
Genes: Kv4.1 KCND1
Simulation Environment: GENESIS
Edgerton JR, Hanson JE, Günay C, Jaeger D. (2010). Dendritic sodium channels regulate network integration in globus pallidus neurons: a modeling study. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]
Edgerton JR, Jaeger D. (2011). Dendritic sodium channels promote active decorrelation and reduce phase locking to parkinsonian input oscillations in model globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]