Globus pallidus neuron models with differing dendritic Na channel expression (Edgerton et al., 2010)


A set of 9 multi-compartmental rat GP neuron models (585 compartments) differing only in their expression of dendritic fast sodium channels were compared in their synaptic integration properties. Dendritic fast sodium channels were found to increase the importance of distal synapses (both excitatory AND inhibitory), increase spike timing variability with in vivo-like synaptic input, and make the model neurons highly sensitive to clustered synchronous excitation.

Model Type: Neuron or other electrically excitable cell; Axon; Synapse; Channel/Receptor; Dendrite

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Globus pallidus neuron

Currents: I Na,p; I Na,t; I A; I K; I h; I K,Ca; I Calcium

Receptors: GabaA; AMPA

Genes: Kv4.1 KCND1

Transmitters: Gaba; Glutamate

Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Coincidence Detection; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Synaptic Integration

Simulation Environment: GENESIS

Implementer(s): Gunay, Cengiz [cgunay at emory.edu]; Edgerton, Jeremy R. [jedgert at emory.edu]; Hanson, Jesse E.; Jaeger, Dieter [djaeger at emory.edu]

References:

Edgerton JR, Hanson JE, G√ľnay C, Jaeger D. (2010). Dendritic sodium channels regulate network integration in globus pallidus neurons: a modeling study. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Edgerton JR, Jaeger D. (2011). Dendritic sodium channels promote active decorrelation and reduce phase locking to parkinsonian input oscillations in model globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]


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