A model for recurrent spreading depolarizations (Conte et al. 2017)

A detailed biophysical model for a neuron/astrocyte network is developed in order to explore mechanisms responsible for cortical spreading depolarizations. This includes a model for the Na+-glutamate transporter, which allows for a detailed description of reverse glutamate uptake. In particular, we consider the specific roles of elevated extracellular glutamate and K+ in the initiation, propagation and recurrence of spreading depolarizations.

Model Type: Extracellular; Glia; Neuron or other electrically excitable cell

Cell Type(s): Astrocyte

Currents: I K; I Na,p; I Cl, leak; Na/K pump; Na+-glutamate transporter

Receptors: Glutamate

Transmitters: Glutamate

Model Concept(s): Detailed Neuronal Models; Potassium buffering; Spreading depression; Spreading depolarization

Simulation Environment: XPPAUT

Implementer(s): Terman, David [terman at math.ohio-state.edu]


Conte C, Lee R, Sarkar M, Terman D. (2018). A mathematical model of recurrent spreading depolarizations. Journal of computational neuroscience. 44 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.