Complex model of a pyramidal CA1-neuron, adapted from Royeck, M., et al. Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of neurophysiology 100, 2361-2380 (2008). It contains a biophysically realistic morphology comprising 265 compartments (829 segments) and 15 different distributed Ca2+- and/or voltage-dependent conductances.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I p,q; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium
Genes: Nav SCN1B
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models; Epilepsy
Simulation Environment: NEURON
Implementer(s): Horstmann, Marie-Therese [mhorstma at uni-bonn.de]
References:
Wimmer VC et al. (2010). Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. The Journal of clinical investigation. 120 [PubMed]