Complex CA1-neuron to study AP initiation (Wimmer et al. 2010)


Wimmer VC et al. (2010). Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. The Journal of clinical investigation. 120 [PubMed]

See more from authors: Wimmer VC · Reid CA · Mitchell S · Richards KL · Scaf BB · Leaw BT · Hill EL · Royeck M · Horstmann MT · Cromer BA · Davies PJ · Xu R · Lerche H · Berkovic SF · Beck H · Petrou S

References and models cited by this paper

Abramoff MD, Magelhaes PJ, Ram SJ. (2004). Image Processing with ImageJ Biophotonics Int. 11

Aman TK et al. (2009). Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Audenaert D et al. (2003). A deletion in SCN1B is associated with febrile seizures and early-onset absence epilepsy. Neurology. 61 [PubMed]

Barela AJ et al. (2006). An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Bender KJ, Trussell LO. (2009). Axon initial segment Ca2+ channels influence action potential generation and timing. Neuron. 61 [PubMed]

Brackenbury WJ et al. (2010). Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Brackenbury WJ, Djamgoz MB, Isom LL. (2008). An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 14 [PubMed]

Brackenbury WJ, Isom LL. (2008). Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. Expert opinion on therapeutic targets. 12 [PubMed]

Chen C et al. (2004). Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Christie SB, De Blas AL. (2003). GABAergic and glutamatergic axons innervate the axon initial segment and organize GABA(A) receptor clusters of cultured hippocampal pyramidal cells. The Journal of comparative neurology. 456 [PubMed]

Cooper DC, Chung S, Spruston N. (2005). Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. PLoS biology. 3 [PubMed]

Devaux JJ, Kleopa KA, Cooper EC, Scherer SS. (2004). KCNQ2 is a nodal K+ channel. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Dubé C et al. (2006). Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain : a journal of neurology. 129 [PubMed]

Duflocq A, Le Bras B, Bullier E, Couraud F, Davenne M. (2008). Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments. Molecular and cellular neurosciences. 39 [PubMed]

Ernst SJ, Aguilar-Bryan L, Noebels JL. (2009). Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion. Endocrinology. 150 [PubMed]

Fry M, Porter DM, Maue RA. (2003). Adenoviral-mediated expression of functional Na+ channel beta1 subunits tagged with a yellow fluorescent protein. Journal of neuroscience research. 74 [PubMed]

Garrido JJ et al. (2003). Dynamic compartmentalization of the voltage-gated sodium channels in axons. Biology of the cell. 95 [PubMed]

Hines ML, Carnevale NT. (2006). The NEURON Book.

Hu W et al. (2009). Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nature neuroscience. 12 [PubMed]

Isom LL et al. (1995). Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line. The Journal of biological chemistry. 270 [PubMed]

Kole MH et al. (2008). Action potential generation requires a high sodium channel density in the axon initial segment. Nature neuroscience. 11 [PubMed]

Kress GJ, Dowling MJ, Eisenman LN, Mennerick S. (2010). Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons. Hippocampus. 20 [PubMed]

Lein ES et al. (2007). Genome-wide atlas of gene expression in the adult mouse brain. Nature. 445 [PubMed]

Lorincz A, Nusser Z. (2008). Cell-type-dependent molecular composition of the axon initial segment. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

McEwen DP, Isom LL. (2004). Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules. The Journal of biological chemistry. 279 [PubMed]

McEwen DP, Meadows LS, Chen C, Thyagarajan V, Isom LL. (2004). Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. The Journal of biological chemistry. 279 [PubMed]

Meadows LS et al. (2002). Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Meeks JP, Mennerick S. (2007). Action potential initiation and propagation in CA3 pyramidal axons. Journal of neurophysiology. 97 [PubMed]

Morimoto T, Nagao H, Sano N, Takahashi M, Matsuda H. (1991). Electroencephalographic study of rat hyperthermic seizures. Epilepsia. 32 [PubMed]

Moulding HD, Martuza RL, Rabkin SD. (2000). Clinical mutations in the L1 neural cell adhesion molecule affect cell-surface expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Oakley JC, Kalume F, Yu FH, Scheuer T, Catterall WA. (2009). Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Ogawa Y, Rasband MN. (2008). The functional organization and assembly of the axon initial segment. Current opinion in neurobiology. 18 [PubMed]

Ogiwara I et al. (2007). Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Palmer LM, Stuart GJ. (2006). Site of action potential initiation in layer 5 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Papale LA et al. (2009). Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice. Human molecular genetics. 18 [PubMed]

Patino GA et al. (2009). A functional null mutation of SCN1B in a patient with Dravet syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Qu Y et al. (2001). Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits. Molecular and cellular neurosciences. 18 [PubMed]

Qu Y et al. (1999). Functional roles of the extracellular segments of the sodium channel alpha subunit in voltage-dependent gating and modulation by beta1 subunits. The Journal of biological chemistry. 274 [PubMed]

Ratcliffe CF, Westenbroek RE, Curtis R, Catterall WA. (2001). Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain. The Journal of cell biology. 154 [PubMed]

Royeck M et al. (2008). Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of neurophysiology. 100 [PubMed]

Scheffer IE et al. (2007). Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. Brain : a journal of neurology. 130 [PubMed]

Scheffer IE, Zhang YH, Jansen FE, Dibbens L. (2009). Dravet syndrome or genetic (generalized) epilepsy with febrile seizures plus? Brain & development. 31 [PubMed]

Shaner NC et al. (2004). Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nature biotechnology. 22 [PubMed]

Spampanato J et al. (2004). A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Stuart G, Häusser M. (1994). Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron. 13 [PubMed]

Tang B et al. (2009). A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiology of disease. 35 [PubMed]

Thomas EA et al. (2009). Heat opens axon initial segment sodium channels: a febrile seizure mechanism? Annals of neurology. 66 [PubMed]

Thomas EA, Xu R, Petrou S. (2007). Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits. Neuroscience. 147 [PubMed]

Van Wart A, Trimmer JS, Matthews G. (2007). Polarized distribution of ion channels within microdomains of the axon initial segment. The Journal of comparative neurology. 500 [PubMed]

Wallace RH et al. (1998). Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nature genetics. 19 [PubMed]

Watanabe H et al. (2008). Sodium channel ß1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. The Journal of clinical investigation. 118 [PubMed]

Wimmer VC, Nevian T, Kuner T. (2004). Targeted in vivo expression of proteins in the calyx of Held. Pflugers Archiv : European journal of physiology. 449 [PubMed]

Wimmer VC, Reid CA, So EY, Berkovic SF, Petrou S. (2010). Axon initial segment dysfunction in epilepsy. The Journal of physiology. 588 [PubMed]

Xiao ZC et al. (1999). Tenascin-R is a functional modulator of sodium channel beta subunits. The Journal of biological chemistry. 274 [PubMed]

Xu R et al. (2007). Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. Neuroscience. 148 [PubMed]

Yu FH et al. (2006). Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nature neuroscience. 9 [PubMed]

Zhou W, Goldin AL. (2004). Use-dependent potentiation of the Nav1.6 sodium channel. Biophysical journal. 87 [PubMed]

References and models that cite this paper
This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.