Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites (Golding et al 2001)

From reference below and Corrigendum: J Neurophysiol 87:1a, 2002 (better versions of figures 2, 3, 5 and 7 because of poor print quality in the original article; as of 2/2006, these figures are perfectly fine in the PDF of the original article that is currently available from the publisher's WWW site). Examines the anatomical and biophysical factors that account for the fact that retrograde invasion of spikes into the apical dendritic tree past 300 um succeeds in some CA1 pyramidal neurons but fails in others.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I A; I K

Model Concept(s): Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials

Simulation Environment: NEURON (web link to model)

Implementer(s): Spruston, Nelson [Spruston at Northwestern.edu]; Golding, Nace L [golding at mail.utexas.edu]; Kath, William L [kath at northwestern.edu]; Mickus, Timothy

References:

Golding NL, Kath WL, Spruston N. (2001). Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites. Journal of neurophysiology. 86 [PubMed]