Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)

A detailed multicompartmental model was used to study neuronal electroresponsiveness of cerebellar granule cells in rats. Here we show that, in cerebellar granule cells, Na+ channels are enriched in the axon, especially in the hillock, but almost absent from soma and dendrites. Numerical simulations indicated that granule cells have a compact electrotonic structure allowing EPSPs to diffuse with little attenuation from dendrites to axon. The spike arose almost simultaneously along the whole axonal ascending branch and invaded the hillock, whose activation promoted spike back-propagation with marginal delay (<200 micros) and attenuation (<20 mV) into the somato-dendritic compartment. For details check the cited article.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Cerebellum

Cell Type(s): Cerebellum interneuron granule GLU cell

Currents: I A; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow

Model Concept(s): Action Potential Initiation; Active Dendrites; Detailed Neuronal Models; Axonal Action Potentials; Action Potentials; Intrinsic plasticity

Simulation Environment: NEURON

Implementer(s): Diwakar, Shyam [shyam at]


Diwakar S, Magistretti J, Goldfarb M, Naldi G, D'Angelo E. (2009). Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells. Journal of neurophysiology. 101 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.