Molecular layer interneurons in cerebellum encode valence in associative learning (Ma et al 2020)

We used two-photon microscopy to study the role of ensembles of cerebellar molecular layer interneurons (MLIs) in a go-no go task where mice obtain a sugar water reward. In order to begin understanding the circuit basis of our findings in changes in lick behavior with chemogenetics in the go-no go associative learning olfactory discrimination task we generated a simple computational model of MLI interaction with PCs.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Cerebellum; Mouse

Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum interneuron stellate GABA cell

Receptors: AMPA; GabaA

Transmitters: Gaba; Glutamate

Model Concept(s): Action Potentials; Detailed Neuronal Models

Simulation Environment: NEURON

Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br]

References:

Ma M et al. (2020). Molecular layer interneurons in the cerebellum encode for valence in associative learning Nature communications. 11 [PubMed]