A model of ASIC1a and synaptic cleft pH modulating wind-up in wide dynamic range neurons (Delrocq)

We introduce a model of ASIC1a homomeric (and heteromeric) ion channel inserted into a pre-existing model of wide dynamic range (WDR) neuron of the spinal cord together with a novel synaptic cleft acidification mechanism. This computational model shows a dual contribution of the ASIC1a channels to wind-up, a facilitation mechanism of WDR neurons, which has been verified experimentally: inhibiting or maximally activating ASICs reduce wind-up. The wind-up inhibition by activation of ASICs is likely mediated by calcium influx and calcium-activated potassium channels.

Model Type: Channel/Receptor; Synapse; Neuron or other electrically excitable cell; Realistic Network

Cell Type(s): Wide dynamic range neuron

Currents: I Calcium; I Potassium; I Sodium

Model Concept(s): Facilitation; Detailed Neuronal Models; Ion Channel Kinetics; Pain processing

Simulation Environment: NEURON; Python


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