A model of a CA1 pyramidal neuron containing a biophysically realistic morphology and 15 distributed voltage and Ca2+-dependent conductances. Repetitive firing is modulated by maximal conductance and the voltage dependence of the persistent Na+ current (INaP).
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,p; I Na,t; I p,q; I A; I K,leak; I M; I K,Ca; I CAN; I Calcium; ATP-senstive potassium current
Model Concept(s): Detailed Neuronal Models; Epilepsy
Simulation Environment: NEURON
Implementer(s): Horstmann, Marie-Therese [mhorstma at uni-bonn.de]
References:
Uebachs M et al. (2010). Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]