CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)


Uebachs M et al. (2010). Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

See more from authors: Uebachs M · Opitz T · Royeck M · Dickhof G · Horstmann MT · Isom LL · Beck H

References and models cited by this paper

Brackenbury WJ et al. (2010). Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Brackenbury WJ, Isom LL. (2008). Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. Expert opinion on therapeutic targets. 12 [PubMed]

Catterall WA. (1999). Molecular properties of brain sodium channels: an important target for anticonvulsant drugs. Advances in neurology. 79 [PubMed]

Chen C et al. (2002). Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proceedings of the National Academy of Sciences of the United States of America. 99 [PubMed]

Chen C et al. (2004). Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Ellerkmann RK et al. (2003). Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience. 119 [PubMed]

Ellerkmann RK, Riazanski V, Elger CE, Urban BW, Beck H. (2001). Slow recovery from inactivation regulates the availability of voltage-dependent Na(+) channels in hippocampal granule cells, hilar neurons and basket cells. The Journal of physiology. 532 [PubMed]

Fry M. (2006). Developmental expression of Na+ currents in mouse Purkinje neurons. The European journal of neuroscience. 24 [PubMed]

Gastaldi M, Robaglia-Schlupp A, Massacrier A, Planells R, Cau P. (1998). mRNA coding for voltage-gated sodium channel beta2 subunit in rat central nervous system: cellular distribution and changes following kainate-induced seizures. Neuroscience letters. 249 [PubMed]

Grieco TM, Malhotra JD, Chen C, Isom LL, Raman IM. (2005). Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current. Neuron. 45 [PubMed]

Hines ML, Carnevale NT. (2001). NEURON: a tool for neuroscientists. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 7 [PubMed]

Hu H, Vervaeke K, Storm JF. (2002). Two forms of electrical resonance at theta frequencies, generated by M-current, h-current and persistent Na+ current in rat hippocampal pyramidal cells. The Journal of physiology. 545 [PubMed]

Isom LL. (2001). Sodium channel beta subunits: anything but auxiliary. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 7 [PubMed]

Isom LL et al. (1995). Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line. The Journal of biological chemistry. 270 [PubMed]

Lopez-Santiago LF et al. (2006). Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Lucas PT, Meadows LS, Nicholls J, Ragsdale DS. (2005). An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin. Epilepsy research. 64 [PubMed]

Meadows LS, Chen YH, Powell AJ, Clare JJ, Ragsdale DS. (2002). Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary beta 1, beta 2 and beta 3 subunits. Neuroscience. 114 [PubMed]

Meadows LS, Isom LL. (2005). Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes. Cardiovascular research. 67 [PubMed]

Nicot A, Ratnakar PV, Ron Y, Chen CC, Elkabes S. (2003). Regulation of gene expression in experimental autoimmune encephalomyelitis indicates early neuronal dysfunction. Brain : a journal of neurology. 126 [PubMed]

Patino GA et al. (2009). A functional null mutation of SCN1B in a patient with Dravet syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Qu Y et al. (2001). Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits. Molecular and cellular neurosciences. 18 [PubMed]

Ragsdale DS, Avoli M. (1998). Sodium channels as molecular targets for antiepileptic drugs. Brain research. Brain research reviews. 26 [PubMed]

Remy S et al. (2003). A novel mechanism underlying drug resistance in chronic epilepsy. Annals of neurology. 53 [PubMed]

Rogawski MA, Löscher W. (2004). The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nature medicine. 10 [PubMed]

Royeck M et al. (2008). Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of neurophysiology. 100 [PubMed]

Sashihara S, Greer CA, Oh Y, Waxman SG. (1996). Cell-specific differential expression of Na(+)-channel beta 1-subunit mRNA in the olfactory system during postnatal development and after denervation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Schaub C, Uebachs M, Beck H. (2007). Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy. Epilepsia. 48 [PubMed]

Sekerli M, Del Negro CA, Lee RH, Butera RJ. (2004). Estimating action potential thresholds from neuronal time-series: new metrics and evaluation of methodologies. IEEE transactions on bio-medical engineering. 51 [PubMed]

Toib A, Lyakhov V, Marom S. (1998). Interaction between duration of activity and time course of recovery from slow inactivation in mammalian brain Na+ channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Vervaeke K, Hu H, Graham LJ, Storm JF. (2006). Contrasting effects of the persistent Na+ current on neuronal excitability and spike timing. Neuron. 49 [PubMed]

Xu R et al. (2007). Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. Neuroscience. 148 [PubMed]

References and models that cite this paper

Bianchi D et al. (2022). Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs Biophysical journal. 121 [PubMed]

Das A, Narayanan R. (2015). Active dendrites mediate stratified gamma-range coincidence detection in hippocampal model neurons. The Journal of physiology. 593 [PubMed]

Guet-McCreight A, Camiré O, Topolnik L, Skinner FK. (2016). Using a Semi-Automated Strategy to Develop Multi-Compartment Models That Predict Biophysical Properties of Interneuron-Specific 3 (IS3) Cells in Hippocampus. eNeuro. 3 [PubMed]

Morris G et al. (2017). Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]

Reetz O, Stadler K, Strauss U. (2014). Protein kinase C activation mediates interferon-ß-induced neuronal excitability changes in neocortical pyramidal neurons. Journal of neuroinflammation. 11 [PubMed]

Tomko M, Benuskova L, Jedlicka P. (2021). A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit. Scientific reports. 11 [PubMed]

Welday AC, Shlifer IG, Bloom ML, Zhang K, Blair HT. (2011). Cosine directional tuning of theta cell burst frequencies: evidence for spatial coding by oscillatory interference. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

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