Here we employ the HippoUnit tests to optimize and validate our new compartmental model with reduced morphology. We show that our model is able to account for the following six well-established characteristic anatomical and physiological properties of CA1 pyramidal cells: (1) The reduced dendritic morphology contains all major dendritic branch classes. In addition to anatomy, the model reproduces also 5 key physiological features, including (2) somatic electrophysiological responses, (3) depolarization block, (4) EPSP attenuation (5) action potential (AP) backpropagation, and (6) synaptic integration at oblique dendrites.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I h; Ca pump; I K; I K,Ca; I Calcium; I CAN; I M; I Na,t; I A; I_KD; I L high threshold; I T low threshold
Model Concept(s): Action Potentials; Active Dendrites; Dendritic Action Potentials; Depolarization block; Parameter Fitting; Synaptic Integration
Simulation Environment: NEURON; Python
References:
Tomko M, Benuskova L, Jedlicka P. (2021). A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit. Scientific reports. 11 [PubMed]