A conductance base model of intrinsic neurons neurons in the gastrointestinal tract. The model contains all the major voltage-gated and calcium-gated currents observed in these neurons. This model can reproduce physiological observations such as the response to multiple brief depolarizing currents, prolonged depolarizing currents and hyperpolarizing currents. This model can be used to predict how different currents influence the excitability of intrinsic sensory neurons in the gut.
Cell Type(s): Gastrointestinal tract intrinsic sensory neuron
Simulation Environment: NEURON
Implementer(s): Chambers, Jordan [jordandchambers at gmail.com]
Chambers JD, Bornstein JC, Gwynne RM, Koussoulas K, Thomas EA. (2014). A detailed, conductance-based computer model of intrinsic sensory neurons of the gastrointestinal tract. American journal of physiology. Gastrointestinal and liver physiology. 307 [PubMed]