Striatal D1R medium spiny neuron, including a subcellular DA cascade (Lindroos et al 2018)

We are investigating how dopaminergic modulation of single channels can be combined to make the D1R possitive MSN more excitable. We also connect multiple channels to substrates of a dopamine induced subcellular cascade to highlight that the classical pathway is too slow to explain DA induced kinetics in the subsecond range (Howe and Dombeck, 2016. doi: 10.1038/nature18942)

Model Type: Axon; Channel/Receptor; Dendrite; Molecular Network; Synapse; Neuron or other electrically excitable cell

Region(s) or Organism(s): Basal ganglia; Striatum

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum spiny neuron

Currents: I A; I A, slow; I Calcium; I CAN; I K; I K,Ca; I K,leak; I Krp; I Na,t; I Potassium; I R; I T low threshold; Kir

Receptors: D1; Dopaminergic Receptor; AMPA; Gaba; NMDA

Transmitters: Dopamine; Gaba; Glutamate

Model Concept(s): Action Potentials; Detailed Neuronal Models; Electrical-chemical; G-protein coupled; Membrane Properties; Neuromodulation; Multiscale; Synaptic noise

Simulation Environment: NEURON; Python

Implementer(s): Lindroos, Robert [robert.lindroos at]; Du, Kai [kai.du at]; Keller, Daniel ; Kozlov, Alexander [akozlov at]


Lindroos R et al. (2018). Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2. Frontiers in neural circuits. 12 [PubMed]

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