Modelling platform of the cochlear nucleus and other auditory circuits (Manis & Compagnola 2018)

"Models of the auditory brainstem have been an invaluable tool for testing hypotheses about auditory information processing and for highlighting the most important gaps in the experimental literature. Due to the complexity of the auditory brainstem, and indeed most brain circuits, the dynamic behavior of the system may be difficult to predict without a detailed, biologically realistic computational model. Despite the sensitivity of models to their exact construction and parameters, most prior models of the cochlear nucleus have incorporated only a small subset of the known biological properties. This confounds the interpretation of modelling results and also limits the potential future uses of these models, which require a large effort to develop. To address these issues, we have developed a general purpose, bio-physically detailed model of the cochlear nucleus for use both in testing hypotheses about cochlear nucleus function and also as an input to models of downstream auditory nuclei. The model implements conductance-based Hodgkin-Huxley representations of cells using a Python-based interface to the NEURON simulator. ..."

Model Type: Neuron or other electrically excitable cell; Realistic Network

Region(s) or Organism(s): Brainstem; Auditory brainstem

Cell Type(s): Cochlear nucleus pyramidal/fusiform GLU cell; Cochlear nucleus octopus GLU cell; Cochlear nucleus bushy GLU cell

Currents: I Potassium; I Na,t; I K,Ca; I p,q; I h; KCNQ1; I K; Kir; I_Ks; I Sodium; I_KHT

Receptors: AMPA; NMDA; Glycine

Genes: Nav1.1 SCN1A

Model Concept(s): Action Potentials; Information transfer; Detailed Neuronal Models; Calcium dynamics

Simulation Environment: Python; NEURON

Implementer(s): Manis, Paul B [PManis at]; Compagnola, Luke


Manis PB, Campagnola L. (2018). A biophysical modelling platform of the cochlear nucleus and other auditory circuits: From channels to networks. Hearing research. 360 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.