We study the synchronisation of neurons in a realistic model under the Hodgkin-Huxley dynamics. To focus on the role of the different locations of the excitatory synapses, we use two identical neurons where the set of input signals is grouped at two different distances from the soma. Synchronisation is studied using phase spiking correlation as a function of various parameters such as the distance from the soma of one of the synaptic groups, the inhibition weight and the associated activation delay. We found that the neurons' spiking activity depends nonmonotonically on the relative dendritic location of the synapses and their inhibitory weight, whereas the synchronisation measure always decreases with inhibition, and strongly depends on its activation time delay.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: Ca pump; I A; I CAN; I Calcium; I K; I K,Ca; I L high threshold; I M; I Na,t; I T low threshold; I h; I_KD
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Model Concept(s): Action Potentials; Detailed Neuronal Models; Methods
Simulation Environment: NEURON
Implementer(s): Fiasconaro, Alessandro; Migliore, Michele [Michele.Migliore at Yale.edu]
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