"... We simulated detailed conductance-based models of TTCs (Layer 5 thick tufted pyramidal cells) forming recurrent microcircuits that were interconnected as found experimentally; the network was embedded in a realistic background synaptic activity. ... Our findings indicate that dendritic nonlinearities are pivotal in controlling the gain and the computational functions of TTCs microcircuits, which serve as a dominant output source for the neocortex. "
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L5/6 pyramidal GLU cell
Simulation Environment: NEURON
Implementer(s): Hay, Etay [etay.hay at mail.huji.ac.il]