CA1 pyramidal neuron: Persistent Na current mediates steep synaptic amplification (Hsu et al 2018)

This paper shows that persistent sodium current critically contributes to the subthreshold nonlinear dynamics of CA1 pyramidal neurons and promotes rapidly reversible conversion between place-cell and silent-cell in the hippocampus. A simple model built with realistic axo-somatic voltage-gated sodium channels in CA1 (Carter et al., 2012; Neuron 75, 1081–1093) demonstrates that the biophysics of persistent sodium current is sufficient to explain the synaptic amplification effects. A full model built previously (Grienberger et al., 2017; Nature Neuroscience, 20(3): 417–426) with detailed morphology, ion channel types and biophysical properties of CA1 place cells naturally reproduces the steep voltage dependence of synaptic responses.

Model Type: Synapse; Channel/Receptor; Neuron or other electrically excitable cell; Axon; Dendrite

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Abstract single compartment conductance based cell

Currents: I Sodium; I A; I M; I h; I K

Receptors: AMPA; NMDA

Transmitters: Glutamate

Model Concept(s): Ion Channel Kinetics; Membrane Properties; Synaptic Integration; Synaptic Amplification; Place cell/field; Active Dendrites; Conductance distributions; Detailed Neuronal Models; Electrotonus; Markov-type model

Simulation Environment: NEURON

Implementer(s): Hsu, Ching-Lung [hsuc at]; Milstein, Aaron D. [aaronmil at]


Hsu CL, Zhao X, Milstein AD, Spruston N. (2018). Persistent sodium current mediates the steep voltage dependence of spatial coding in hippocampal pyramidal neurons Neuron. 99

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