"...We implemented a biophysically-based computational model of a cortical column comprising neurons with realistic morphology and representative synapses. We quantified the spatial effects of single pulses and short trains of ICMS, including the volume of activated neurons and the density of activated neurons as a function of stimulation intensity..."
Model Type: Synapse; Realistic Network; Neuron or other electrically excitable cell; Axon
Region(s) or Organism(s): Neocortex
Cell Type(s): Myelinated neuron
Receptors: AMPA; GabaA; GabaB; NMDA
Model Concept(s): Intracortical Microstimulation; Action Potentials; Detailed Neuronal Models
Simulation Environment: NEURON; MATLAB
Implementer(s): Kumaravelu, Karthik [kk192 at duke.edu]
References:
Kumaravelu K, Sombeck J, Miller LE, Bensmaia SJ, Grill WM. (2022). Stoney vs. Histed: Quantifying the spatial effects of intracortical microstimulation Brain stimulation. 15 [PubMed]