Effects of neural morphology on global and focal NMDA-spikes (Poleg-Polsky 2015)

This entry contains the NEURON files required to recreate figures 4-8 of the paper "Effects of Neural Morphology and Input Distribution on Synaptic Processing by Global and Focal NMDA-spikes" by Alon Poleg-Polsky

Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex layer 4 neuron

Currents: I N; I K; I K,leak

Receptors: AMPA; NMDA

Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models; Synaptic Integration; Synaptic-input statistic; Dendritic Bistability

Simulation Environment: NEURON

Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il]

References:

Poleg-Polsky A. (2015). Effects of Neural Morphology and Input Distribution on Synaptic Processing by Global and Focal NMDA-Spikes. PloS one. 10 [PubMed]