"...We show that dopamine oppositely shapes responses to convergent excitatory inputs in mouse striosome and matrix striatal spiny projection neurons (SPNs). Activation of postsynaptic D1 dopamine receptors promoted the generation of long-lasting synaptically evoked 'up-states' in matrix SPNs but opposed it in striosomes, which were more excitable under basal conditions. Differences in dopaminergic modulation were mediated, in part, by dendritic voltage-gated calcium channels (VGCCs): pharmacological manipulation of L-type VGCCs reversed compartment-specific responses to D1 receptor activation..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia; Striatum; Mouse
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum spiny neuron
Currents: I A; I A, slow; I Ca,p; I Cl,Ca; I K,Ca; I Krp; I Na, slow inactivation; I T low threshold; Kir
Model Concept(s): Active Dendrites; Calcium dynamics; Detailed Neuronal Models
Simulation Environment: MOOSE/PyMOOSE
Implementer(s): Dorman, Daniel B ; Blackwell, Avrama [avrama at gmu.edu]
References:
Prager EM et al. (). Dopamine oppositely modulates state transitions in striosome and matrix direct pathway striatal spiny neurons Neuron. 108(6)