" ... Here, combining data from fluorescence-targeted dendritic recordings and Ca2+ imaging from low-threshold spiking cells in rat brain slices with computational modeling, the cellular mechanism responsible for LTS (Low Threshold Spike) generation is established. ..." " ... Using dendritic recording, 2-photon glutamate uncaging, and computational modeling, we investigated how rat dorsal lateral geniculate nucleus thalamocortical neurons integrate excitatory corticothalamic feedback. ..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Thalamus
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell
Currents: I T low threshold; I Calcium; I h
Transmitters: Glutamate
Model Concept(s): Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Active Dendrites; Action Potential Initiation; Calcium dynamics
Simulation Environment: NEURON
Implementer(s): Connelly, William [connelly.bill at gmail.com]
References:
Connelly WM, Crunelli V, Errington AC. (2016). Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36 [PubMed]
Connelly WM, Crunelli V, Errington AC. (2015). The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]