NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)

Cannabinoid withdrawal produces a hypofunction of dopaminergic neurons targeting medium spiny neurons (MSN) of the forebrain. Administration of a CB1 receptor antagonist to control rats provoked structural abnormalities, reminiscent of those observed in withdrawal conditions and support the regulatory role of cannabinoids in neurogenesis, axonal growth and synaptogenesis. Experimental observations were incorporated into a realistic computational model which predicts a strong reduction in the excitability of morphologically-altered MSN, yielding a significant reduction in action potential output. These paper provided direct morphological evidence for functional abnormalities associated with cannabinoid dependence at the level of dopaminergic neurons and their post synaptic counterpart, supporting a hypodopaminergic state as a distinctive feature of the “addicted brain”.

Model Type: Dendrite

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Nucleus accumbens spiny projection neuron

Currents: I Na,t; I A; I Potassium; I A, slow; I Krp

Receptors: AMPA

Transmitters: Glutamate

Model Concept(s): Action Potential Initiation; Activity Patterns; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Addiction

Simulation Environment: NEURON

Implementer(s): Migliore, Michele [Michele.Migliore at]


Spiga S, Lintas A, Migliore M, Diana M. (2010). Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence. Addiction biology. 15 [PubMed]

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