FHF2KO and Wild-Type Mouse Cardiomyocyte Strands (Park et al 2020)

Fhf2WT and Fhf2KO mouse ventricular cardiomyocyte models differ only in the inactivation gating of voltage-gated sodium channels. Cardiomyocyte linear strands were constructed by electrically coupling 111 model cells. Action potential conduction through the Fhf2KO strand is blocked by a range of stressors, including temperature elevation or reduction in sodium, calcium, or gap junctional conductance densities. Conduction through the Fhf2WT model strand is resistant to these stresses.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Cardiac ventricular cell

Currents: I K; Na/K pump; I L high threshold; I Na,t

Model Concept(s): Conduction failure; Detailed Neuronal Models; Heart disease; Ion Channel Kinetics; Temperature

Simulation Environment: NEURON

Implementer(s): Goldfarb, Mitchell goldfarb at genectr.hunter.cuny.edu]; Solinas, Sergio [solinas at unipv.it]


Park DS et al. (2020). Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart. Circulation research. 127 [PubMed]

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