This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron
Currents: I Sodium; I Potassium; Kir
Receptors: D1; D2; GabaA; Glutamate
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's
Simulation Environment: GENESIS
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com]
References:
Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT. (2015). Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]