Inhibitory synaptic inputs to Renshaw cells are concentrated on the soma and the juxtasomatic dendrites. In the present study, we investigated whether this proximal bias leads to more effective inhibition under different neuronal operating conditions. Using compartmental models based on detailed anatomical measurements of intracellularly stained Renshaw cells, we compared the inhibition produced by GABAA synapses when distributed with a proximal bias to the inhibition produced when the same synapses were distributed uniformly. See paper for more and details.
Model Type: Neuron or other electrically excitable cell
Simulation Environment: SABER
Bui TV, Dewey DE, Fyffe RE, Rose PK. (2005). Comparison of the inhibition of Renshaw cells during subthreshold and suprathreshold conditions using anatomically and physiologically realistic models. Journal of neurophysiology. 94 [PubMed]