Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009)

Simulations used in the paper. Voltage responses to current injections in different tuft locations; NMDA and calcium spike generation. Summation of multiple input distribution.

Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I L high threshold; I p,q; I A; I K,leak; I K,Ca; I Sodium

Receptors: GabaA; AMPA; NMDA

Transmitters: Gaba; Glutamate

Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Synaptic Integration

Simulation Environment: NEURON

Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il]

References:

Larkum ME, Nevian T, Sandler M, Polsky A, Schiller J. (2009). Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. Science (New York, N.Y.). 325 [PubMed]