Systematic integration of data into multi-scale models of mouse primary V1 (Billeh et al 2020)

"Highlights • Two network models of the mouse primary visual cortex are developed and released • One uses compartmental-neuron models and the other point-neuron models • The models recapitulate observations from in vivo experimental data • Simulations identify experimentally testable predictions about cortex circuitry"

Model Type: Realistic Network

Region(s) or Organism(s): Neocortex; Mouse

Cell Type(s): Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex V1 interneuron chandelier SOM GABA cell; Neocortex V1 L4 stellate GLU cell; Neocortex L5/6 pyramidal GLU cell; Neocortex layer 2-3 interneuron; Neocortex layer 4 interneuron; Neocortex layer 4 pyramidal cell; Neocortex layer 5 interneuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking regular (RS) neuron

Currents: I L high threshold; I h; I T low threshold; I M; I K; I Krp; I A; I Na,t; I Na,p; I K,Ca

Model Concept(s): Vision; Simplified Models; Detailed Neuronal Models; Activity Patterns

Simulation Environment: NEURON (web link to model); NEST (web link to model)

References:

Billeh YN et al. (2020). Systematic Integration of Structural and Functional Data into Multi-scale Models of Mouse Primary Visual Cortex. Neuron. 106 [PubMed]