"We developed a detailed model of macaque auditory thalamocortical circuits, including primary auditory cortex (A1), medial geniculate body (MGB), and thalamic reticular nucleus, utilizing the NEURON simulator and NetPyNE tool. The A1 model simulates a cortical column with over 12,000 neurons and 25 million synapses, incorporating data on cell-type-specific neuron densities, morphology, and connectivity across six cortical layers. It is reciprocally connected to the MGB thalamus, which includes interneurons and core and matrix-layer-specific projections to A1. The model simulates multiscale measures, including physiological firing rates, local field potentials (LFPs), current source densities (CSDs), and electroencephalography (EEG) signals. Laminar CSD patterns, during spontaneous activity and in response to broadband noise stimulus trains, mirror experimental findings. Physiological oscillations emerge spontaneously across frequency bands comparable to those recorded in vivo. We elucidate population-specific contributions to observed oscillation events and relate them to firing and presynaptic input patterns. The model offers a quantitative theoretical framework to integrate and interpret experimental data and predict its underlying cellular and circuit mechanisms."
Model Type: Realistic Network
Region(s) or Organism(s): Auditory cortex; Thalamus; Auditory brainstem
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex deep neurogliaform interneuron; Neocortex spiny stellate cell; Neocortex superficial neurogliaform interneuron
Currents: I A; I K,Ca; I L high threshold; I N; I Potassium; I Sodium; I T low threshold; I h
Receptors: GabaB; GabaA; AMPA; NMDA
Genes:
Transmitters:
Model Concept(s): Evoked LFP; Audition; Laminar Connectivity; Oscillations
Simulation Environment: NEURON; NetPyNE
Implementer(s): Dura-Bernal, Salvador [salvadordura at gmail.com]; Griffith, Erica; Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org]
References:
Dura-Bernal S et al. (2023). Data-driven multiscale model of macaque auditory thalamocortical circuits reproduces in vivo dynamics. Cell reports. 42 [PubMed]