"Gamma oscillations are thought to play a role in learning and memory. Two distinct bands, slow (25-50 Hz) and fast (65-100 Hz) gamma, have been identified in area CA1 of the rodent hippocampus. Slow gamma is phase-locked to activity in area CA3 and presumably driven by the Schaffer collaterals. We used a combination of computational modeling and in vitro electrophysiology in hippocampal slices of male rats to test whether CA1 neurons responded to Schaffer collateral stimulation selectively at slow gamma frequencies, and to identify the mechanisms involved. Both approaches demonstrated that in response to temporally precise input at Schaffer collaterals, CA1 pyramidal neurons fire preferentially in the slow gamma range regardless of whether the input is at fast or slow gamma frequencies, suggesting frequency selectivity in CA1 output with respect to CA3 input. In addition, phase-locking, assessed by the vector strength, was more precise for slow gamma than fast gamma input. ..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Model Concept(s): Gamma oscillations
Simulation Environment: NEURON
Implementer(s): Canavier, CC
Combe CL, Canavier CC, Gasparini S. (2018). Intrinsic Mechanisms of Frequency Selectivity in the Proximal Dendrites of CA1 Pyramidal Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]