Python and MATLAB scripts for studying the dual effects of SCZ-related genes on layer 5 pyramidal cell firing and sinoatrial node cell pacemaking properties. The study is based on two L5PC models (Hay et al. 2011, Almog & Korngreen 2014) and SANC models (Kharche et al. 2011, Severi et al. 2012).
Model Type: Neuron or other electrically excitable cell
Model Concept(s): Schizophrenia
Implementer(s): Maki-Marttunen, Tuomo [tuomomm at uio.no]
Mäki-Marttunen T et al. (2017). Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. Translational psychiatry. 7 [PubMed]