Mäki-Marttunen T et al. (2017). Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. Translational psychiatry. 7 [PubMed]

See more from authors: Mäki-Marttunen T · Lines GT · Edwards AG · Tveito A · Dale AM · Einevoll GT · Andreassen OA

References and models cited by this paper

Ahn W, Lee MG, Kim KH, Muallem S. (2003). Multiple effects of SERCA2b mutations associated with Darier's disease. The Journal of biological chemistry. 278 [PubMed]

Almog M, Korngreen A. (2014). A Quantitative Description of Dendritic Conductances and Its Application to Dendritic Excitation in Layer 5 Pyramidal Neurons The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Altomare C et al. (2003). Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node. The Journal of physiology. 549 [PubMed]

Arking DE et al. (2014). Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nature genetics. 46 [PubMed]

Azizan EA et al. (2013). Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nature genetics. 45 [PubMed]

Barbuti A, Baruscotti M, DiFrancesco D. (2007). The pacemaker current: from basics to the clinics. Journal of cardiovascular electrophysiology. 18 [PubMed]

Blackwell KT. (2013). Approaches and tools for modeling signaling pathways and calcium dynamics in neurons. Journal of neuroscience methods. 220 [PubMed]

Bock G et al. (2011). Functional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels. The Journal of biological chemistry. 286 [PubMed]

Brown S. (1997). Excess mortality of schizophrenia. A meta-analysis. The British journal of psychiatry : the journal of mental science. 171 [PubMed]

Cestèle S et al. (2013). Divergent effects of the T1174S SCN1A mutation associated with seizures and hemiplegic migraine. Epilepsia. 54 [PubMed]

Cestèle S et al. (2008). Self-limited hyperexcitability: functional effect of a familial hemiplegic migraine mutation of the Nav1.1 (SCN1A) Na+ channel. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Chen WT et al. (2013). Apamin modulates electrophysiological characteristics of the pulmonary vein and the Sinoatrial Node. European journal of clinical investigation. 43 [PubMed]

Cordeiro JM et al. (2009). Accelerated inactivation of the L-type calcium current due to a mutation in CACNB2b underlies Brugada syndrome. Journal of molecular and cellular cardiology. 46 [PubMed]

Depil K et al. (2011). Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein. The Journal of biological chemistry. 286 [PubMed]

Devor A et al. (2017). Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular psychiatry. 22 [PubMed]

Dode L et al. (2003). Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses. The Journal of biological chemistry. 278 [PubMed]

Faber ES. (2010). Functional interplay between NMDA receptors, SK channels and voltage-gated Ca2+ channels regulates synaptic excitability in the medial prefrontal cortex. The Journal of physiology. 588 [PubMed]

Fujii K et al. (2014). QT is longer in drug-free patients with schizophrenia compared with age-matched healthy subjects. PloS one. 9 [PubMed]

Glassman AH, Bigger JT. (2001). Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. The American journal of psychiatry. 158 [PubMed]

Gomora JC, Murbartián J, Arias JM, Lee JH, Perez-Reyes E. (2002). Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation. Biophysical journal. 83 [PubMed]

Gottesman II, Shields J. (1967). A polygenic theory of schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 58 [PubMed]

Hasan A, Falkai P, Wobrock T. (2013). Transcranial brain stimulation in schizophrenia: targeting cortical excitability, connectivity and plasticity. Current medicinal chemistry. 20 [PubMed]

Hay E, Hill S, Schürmann F, Markram H, Segev I. (2011). Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS computational biology. 7 [PubMed]

Hohaus A et al. (2005). Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder. The Journal of biological chemistry. 280 [PubMed]

Hu D et al. (2010). Dual variation in SCN5A and CACNB2b underlies the development of cardiac conduction disease without Brugada syndrome. Pacing and clinical electrophysiology : PACE. 33 [PubMed]

International Schizophrenia Consortium et al. (2009). Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 460 [PubMed]

Iop L. (2014). Modeling Cardiac Congenital Diseases: From Mathematic Tools to Human Induced Pluripotent Stem Cells Conference Papers in Science. 2014

Ishii TM, Nakashima N, Ohmori H. (2007). Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation. The Journal of physiology. 579 [PubMed]

Ji Y et al. (2000). Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function. The Journal of biological chemistry. 275 [PubMed]

Jones SL, Stuart GJ. (2013). Different calcium sources control somatic versus dendritic SK channel activation during action potentials. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Kharche S, Yu J, Lei M, Zhang H. (2011). A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases. American journal of physiology. Heart and circulatory physiology. 301 [PubMed]

Kodandaramaiah SB, Franzesi GT, Chow BY, Boyden ES, Forest CR. (2012). Automated whole-cell patch-clamp electrophysiology of neurons in vivo. Nature methods. 9 [PubMed]

Koivumäki JT, Korhonen T, Tavi P. (2011). Impact of sarcoplasmic reticulum calcium release on calcium dynamics and action potential morphology in human atrial myocytes: a computational study. PLoS computational biology. 7 [PubMed]

Kudrnac M et al. (2009). Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2. The Journal of biological chemistry. 284 [PubMed]

Lai MH et al. (2014). BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo. American journal of physiology. Heart and circulatory physiology. 307 [PubMed]

Lakatta EG, DiFrancesco D. (2009). What keeps us ticking: a funny current, a calcium clock, or both? Journal of molecular and cellular cardiology. 47 [PubMed]

Lakatta EG, Maltsev VA, Vinogradova TM. (2010). A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circulation research. 106 [PubMed]

Larkum M. (2013). A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex. Trends in neurosciences. 36 [PubMed]

Laursen TM, Munk-Olsen T, Vestergaard M. (2012). Life expectancy and cardiovascular mortality in persons with schizophrenia. Current opinion in psychiatry. 25 [PubMed]

Lee SH et al. (2012). Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nature genetics. 44 [PubMed]

Lehnart SE et al. (2008). Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. The Journal of clinical investigation. 118 [PubMed]

Lesso H, Li RA. (2003). Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype. The Journal of biological chemistry. 278 [PubMed]

Li N et al. (2015). Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. Circulation. Arrhythmia and electrophysiology. 8 [PubMed]

Lieb A, Scharinger A, Sartori S, Sinnegger-Brauns MJ, Striessnig J. (2012). Structural determinants of CaV1.3 L-type calcium channel gating. Channels (Austin, Tex.). 6 [PubMed]

Link S et al. (2009). Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heart. The Journal of biological chemistry. 284 [PubMed]

Liu H et al. (2011). Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function. The Journal of biological chemistry. 286 [PubMed]

Liu J, Dobrzynski H, Yanni J, Boyett MR, Lei M. (2007). Organisation of the mouse sinoatrial node: structure and expression of HCN channels. Cardiovascular research. 73 [PubMed]

Macquaide N et al. (2015). Ryanodine receptor cluster fragmentation and redistribution in persistent atrial fibrillation enhance calcium release. Cardiovascular research. 108 [PubMed]

Mantegazza M et al. (2005). Identification of an Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures. Proceedings of the National Academy of Sciences of the United States of America. 102 [PubMed]

Mardal KA, Logg A, Wells G. (2012). Automated solution of differential equations by the finite element method: The FEniCS book. 84

Marionneau C et al. (2005). Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. The Journal of physiology. 562 [PubMed]

Markram H. (2012). The human brain project. Scientific American. 306 [PubMed]

Markram H et al. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell. 163 [PubMed]

Massa E, Kelly KM, Yule DI, MacDonald RL, Uhler MD. (1995). Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms. Molecular pharmacology. 47 [PubMed]

Moosmang S et al. (2001). Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. European journal of biochemistry. 268 [PubMed]

Murbartián J, Arias JM, Perez-Reyes E. (2004). Functional impact of alternative splicing of human T-type Cav3.3 calcium channels. Journal of neurophysiology. 92 [PubMed]

Mäki-Marttunen T et al. (2016). Functional Effects of Schizophrenia-Linked Genetic Variants on Intrinsic Single-Neuron Excitability: A Modeling Study. Biological psychiatry. Cognitive neuroscience and neuroimaging. 1 [PubMed]

O'Donnell P. (2008). Increased cortical excitability as a critical element in schizophrenia pathophysiology Cortical Deficits In Schizophrenia.

Papoutsi A, Sidiropoulou K, Cutsuridis V, Poirazi P. (2013). Induction and modulation of persistent activity in a layer V PFC microcircuit model. Frontiers in neural circuits. 7 [PubMed]

Periasamy M et al. (1999). Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. The Journal of biological chemistry. 274 [PubMed]

Pinggera A et al. (2015). CACNA1D de novo mutations in autism spectrum disorders activate Cav1.3 L-type calcium channels. Biological psychiatry. 77 [PubMed]

Podlaski WF et al. (2017). Mapping the function of neuronal ion channels in model and experiment. eLife. 6 [PubMed]

Pérez-Alvarez A, Hernández-Vivanco A, Caba-González JC, Albillos A. (2011). Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells. Journal of neurochemistry. 116 [PubMed]

Ranjan R, Logette E, Petitprez S, Marani M, Mirjia H, Muller EB, et al. (2014). (2014). Automated biophysical characterization of the complete rat Kv-ion channel family Society for Neuroscience Meeting, November 15–19, Washington, DC.

Ray WA, Chung CP, Murray KT, Hall K, Stein CM. (2009). Atypical antipsychotic drugs and the risk of sudden cardiac death. The New England journal of medicine. 360 [PubMed]

Reilly JG, Ayis SA, Ferrier IN, Jones SJ, Thomas SH. (2000). QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet (London, England). 355 [PubMed]

Ripke S et al. (2013). Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature genetics. 45 [PubMed]

Ryan MC, Thakore JH. (2002). Physical consequences of schizophrenia and its treatment: the metabolic syndrome. Life sciences. 71 [PubMed]

SEIFEN E, SCHAER H, MARSHALL JM. (1964). EFFECT OF CALCIUM ON THE MEMBRANE POTENTIALS OF SINGLE PACEMAKER FIBRES AND ATRIAL FIBRES IN ISOLATED RABBITS ATRIA. Nature. 202 [PubMed]

Saha S, Chant D, McGrath J. (2007). A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Archives of general psychiatry. 64 [PubMed]

Schizophrenia Working Group of the Psychiatric Genomics Consortium. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature. 511 [PubMed]

Severi S, Fantini M, Charawi LA, DiFrancesco D. (2012). An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation. The Journal of physiology. 590 [PubMed]

Simms BA, Zamponi GW. (2014). Neuronal voltage-gated calcium channels: structure, function, and dysfunction. Neuron. 82 [PubMed]

Sotoodehnia N et al. (2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature genetics. 42 [PubMed]

Splawski I et al. (2005). Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proceedings of the National Academy of Sciences of the United States of America. 102 [PubMed]

Stary A et al. (2008). Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of Ca V 1.2. Channels (Austin, Tex.). 2 [PubMed]

Stocker M. (2004). Ca(2+)-activated K+ channels: molecular determinants and function of the SK family. Nature reviews. Neuroscience. 5 [PubMed]

Sundnes J et al. (2006). On the computational complexity of the bidomain and the monodomain models of electrophysiology. Annals of biomedical engineering. 34 [PubMed]

Tan BZ et al. (2011). Functional characterization of alternative splicing in the C terminus of L-type CaV1.3 channels. The Journal of biological chemistry. 286 [PubMed]

Tang ZZ et al. (2004). Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunit. The Journal of biological chemistry. 279 [PubMed]

Vanmolkot KR et al. (2007). The novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Mutation in brief #957. Online. Human mutation. 28 [PubMed]

Viskin S et al. (1996). Mode of onset of torsade de pointes in congenital long QT syndrome. Journal of the American College of Cardiology. 28 [PubMed]

Viskin S et al. (2000). Arrhythmias in the congenital long QT syndrome: how often is torsade de pointes pause dependent? Heart (British Cardiac Society). 83 [PubMed]

Volkers L et al. (2011). Nav 1.1 dysfunction in genetic epilepsy with febrile seizures-plus or Dravet syndrome. The European journal of neuroscience. 34 [PubMed]

Wemhöner K et al. (2015). An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities. Frontiers in molecular neuroscience. 8 [PubMed]

Zhang H et al. (2000). Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. American journal of physiology. Heart and circulatory physiology. 279 [PubMed]

Zhang Q et al. (2011). Expression and roles of Cav1.3 (a1D) L-type Ca²+ channel in atrioventricular node automaticity. Journal of molecular and cellular cardiology. 50 [PubMed]

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