This model is developed to study the role of various electrophysiological mechanisms in generating cardiac pacemaking action potentials (APs).The model incorporates membrane ionic currents and intracellular mechanisms contributing to spontaneous mouse SAN APs. The model was validated by testing the functional roles of individual membrane currents in one and multiple parameter analyses.The roles of intracellular Ca2+-handling mechanisms on cardiac pacemaking were also investigated in the model.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Cardiac atrial cell
Simulation Environment: C or C++ program
Implementer(s): Kharche, Sanjay
Kharche S, Yu J, Lei M, Zhang H. (2011). A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases. American journal of physiology. Heart and circulatory physiology. 301 [PubMed]