Biophysically detailed model of the mouse sino-atrial node cell (Kharche et al. 2011)

This model is developed to study the role of various electrophysiological mechanisms in generating cardiac pacemaking action potentials (APs).The model incorporates membrane ionic currents and intracellular mechanisms contributing to spontaneous mouse SAN APs. The model was validated by testing the functional roles of individual membrane currents in one and multiple parameter analyses.The roles of intracellular Ca2+-handling mechanisms on cardiac pacemaking were also investigated in the model.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Cardiac atrial cell

Currents: I N; I K; I Sodium; I Calcium; I Potassium; I_HERG; Na/Ca exchanger; KCNQ1; Na/K pump

Genes: Nav1.1 SCN1A; Nav1.2 SCN2A; HERG KCNH2; Cav3.1 CACNA1G; Cav1.3 CACNA1D; Cav1.2 CACNA1C

Model Concept(s): Action Potential Initiation; Oscillations; Action Potentials; Calcium dynamics; Cardiac pacemaking

Simulation Environment: C or C++ program

Implementer(s): Kharche, Sanjay


Kharche S, Yu J, Lei M, Zhang H. (2011). A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases. American journal of physiology. Heart and circulatory physiology. 301 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.