Biophysically detailed model of the mouse sino-atrial node cell (Kharche et al. 2011)


Kharche S, Yu J, Lei M, Zhang H. (2011). A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases. American journal of physiology. Heart and circulatory physiology. 301 [PubMed]

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References and models cited by this paper

Alig J et al. (2009). Control of heart rate by cAMP sensitivity of HCN channels. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Altomare C et al. (2003). Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node. The Journal of physiology. 549 [PubMed]

Barbuti A, DiFrancesco D. (2008). Control of cardiac rate by "funny" channels in health and disease. Annals of the New York Academy of Sciences. 1123 [PubMed]

Baruscotti M et al. (2011). Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proceedings of the National Academy of Sciences of the United States of America. 108 [PubMed]

Berry RG, Despa S, Fuller W, Bers DM, Shattock MJ. (2007). Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes. Cardiovascular research. 73 [PubMed]

Bogdanov KY et al. (2006). Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state. Circulation research. 99 [PubMed]

Bohn G et al. (2000). Expression of T- and L-type calcium channel mRNA in murine sinoatrial node. FEBS letters. 481 [PubMed]

Boyett MR, Honjo H, Kodama I. (2000). The sinoatrial node, a heterogeneous pacemaker structure. Cardiovascular research. 47 [PubMed]

Chen B, Wu Y, Mohler PJ, Anderson ME, Song LS. (2009). Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells. Journal of molecular and cellular cardiology. 47 [PubMed]

Cho HS, Takano M, Noma A. (2003). The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node. The Journal of physiology. 550 [PubMed]

Clark RB et al. (2004). A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells. American journal of physiology. Heart and circulatory physiology. 286 [PubMed]

Demion M, Bois P, Launay P, Guinamard R. (2007). TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells. Cardiovascular research. 73 [PubMed]

Demir SS, Clark JW, Murphey CR, Giles WR. (1994). A mathematical model of a rabbit sinoatrial node cell. The American journal of physiology. 266 [PubMed]

Denyer JC, Brown HF. (1990). Rabbit sino-atrial node cells: isolation and electrophysiological properties. The Journal of physiology. 428 [PubMed]

Despa S et al. (2005). Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes. Circulation research. 97 [PubMed]

Dokos S, Celler B, Lovell N. (1996). Ion currents underlying sinoatrial node pacemaker activity: a new single cell mathematical model. Journal of theoretical biology. 181 [PubMed]

Faber GM, Rudy Y. (2007). Calsequestrin mutation and catecholaminergic polymorphic ventricular tachycardia: a simulation study of cellular mechanism. Cardiovascular research. 75 [PubMed]

Fukuzaki K, Sato T, Miki T, Seino S, Nakaya H. (2008). Role of sarcolemmal ATP-sensitive K+ channels in the regulation of sinoatrial node automaticity: an evaluation using Kir6.2-deficient mice. The Journal of physiology. 586 [PubMed]

Greenstein JL, Tanskanen AJ, Winslow RL. (2004). Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processes. Annals of the New York Academy of Sciences. 1015 [PubMed]

Guo J, Mitsuiye T, Noma A. (1997). The sustained inward current in sino-atrial node cells of guinea-pig heart. Pflugers Archiv : European journal of physiology. 433 [PubMed]

Guo J, Ono K, Noma A. (1995). A sustained inward current activated at the diastolic potential range in rabbit sino-atrial node cells. The Journal of physiology. 483 ( Pt 1) [PubMed]

Hagiwara N, Irisawa H, Kameyama M. (1988). Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. The Journal of physiology. 395 [PubMed]

Han F, Bossuyt J, Despa S, Tucker AL, Bers DM. (2006). Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circulation research. 99 [PubMed]

Heath BM, Terrar DA. (1996). The deactivation kinetics of the delayed rectifier components IKr and IKs in guinea-pig isolated ventricular myocytes. Experimental physiology. 81 [PubMed]

Herrmann S, Stieber J, Ludwig A. (2007). Pathophysiology of HCN channels. Pflugers Archiv : European journal of physiology. 454 [PubMed]

Herrmann S, Stieber J, Stöckl G, Hofmann F, Ludwig A. (2007). HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. The EMBO journal. 26 [PubMed]

Himeno Y et al. (2011). Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells. American journal of physiology. Heart and circulatory physiology. 300 [PubMed]

Hund TJ, Rudy Y. (2004). Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 110 [PubMed]

Hüser J, Blatter LA, Lipsius SL. (2000). Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells. The Journal of physiology. 524 Pt 2 [PubMed]

Ju YK et al. (2007). Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node. Circulation research. 100 [PubMed]

Kneller J, Ramirez RJ, Chartier D, Courtemanche M, Nattel S. (2002). Time-dependent transients in an ionically based mathematical model of the canine atrial action potential. American journal of physiology. Heart and circulatory physiology. 282 [PubMed]

Kodama I et al. (1997). Regional differences in the role of the Ca2+ and Na+ currents in pacemaker activity in the sinoatrial node. The American journal of physiology. 272 [PubMed]

Krogh-Madsen T et al. (2005). An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells. American journal of physiology. Heart and circulatory physiology. 289 [PubMed]

Kurata Y, Hisatome I, Imanishi S, Shibamoto T. (2002). Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell. American journal of physiology. Heart and circulatory physiology. 283 [PubMed]

Kurata Y, Matsuda H, Hisatome I, Shibamoto T. (2008). Regional difference in dynamical property of sinoatrial node pacemaking: role of na+ channel current. Biophysical journal. 95 [PubMed]

Lakatta EG, Vinogradova TM, Maltsev VA. (2008). The missing link in the mystery of normal automaticity of cardiac pacemaker cells. Annals of the New York Academy of Sciences. 1123 [PubMed]

Lei M et al. (2005). Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a. The Journal of physiology. 567 [PubMed]

Lei M, Honjo H, Kodama I, Boyett MR. (2000). Characterisation of the transient outward K+ current in rabbit sinoatrial node cells. Cardiovascular research. 46 [PubMed]

Lei M et al. (2004). Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking. The Journal of physiology. 559 [PubMed]

Lei M, Zhang H, Grace AA, Huang CL. (2007). SCN5A and sinoatrial node pacemaker function. Cardiovascular research. 74 [PubMed]

Lei M, Zhang H, Kharche S, Higham J. (2011). Functional Roles of Ionic Currents in a Membrane Delimited Mouse Sino-Atrial Node Cell Model (online) Computing in Cardiology. 37

Liao Z, Lockhead D, Larson ED, Proenza C. (2010). Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node. The Journal of general physiology. 136 [PubMed]

Lipsius SL, Hüser J, Blatter LA. (2001). Intracellular Ca2+ release sparks atrial pacemaker activity. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society. 16 [PubMed]

Liu J, Dobrzynski H, Yanni J, Boyett MR, Lei M. (2007). Organisation of the mouse sinoatrial node: structure and expression of HCN channels. Cardiovascular research. 73 [PubMed]

Livshitz L, Rudy Y. (2009). Uniqueness and stability of action potential models during rest, pacing, and conduction using problem-solving environment. Biophysical journal. 97 [PubMed]

Lomax AE, Rose RA, Giles WR. (2003). Electrophysiological evidence for a gradient of G protein-gated K+ current in adult mouse atria. British journal of pharmacology. 140 [PubMed]

Lyashkov AE et al. (2007). Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size. Circulation research. 100 [PubMed]

Maltsev VA, Lakatta EG. (2007). Cardiac pacemaker cell failure with preserved I(f), I(CaL), and I(Kr): a lesson about pacemaker function learned from ischemia-induced bradycardia. Journal of molecular and cellular cardiology. 42 [PubMed]

Maltsev VA, Lakatta EG. (2009). Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. American journal of physiology. Heart and circulatory physiology. 296 [PubMed]

Maltsev VA, Vinogradova TM, Bogdanov KY, Lakatta EG, Stern MD. (2004). Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process. Biophysical journal. 86 [PubMed]

Mangoni ME et al. (2003). Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity. Proceedings of the National Academy of Sciences of the United States of America. 100 [PubMed]

Mangoni ME et al. (2006). Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes. Progress in biophysics and molecular biology. 90 [PubMed]

Mangoni ME, Nargeot J. (2001). Properties of the hyperpolarization-activated current (I(f)) in isolated mouse sino-atrial cells. Cardiovascular research. 52 [PubMed]

Mangoni ME, Nargeot J. (2008). Genesis and regulation of the heart automaticity. Physiological reviews. 88 [PubMed]

Mangoni ME et al. (2006). Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels. Circulation research. 98 [PubMed]

Masumiya H et al. (2003). The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors. FEBS letters. 553 [PubMed]

Matsuura H, Ehara T, Ding WG, Omatsu-Kanbe M, Isono T. (2002). Rapidly and slowly activating components of delayed rectifier K(+) current in guinea-pig sino-atrial node pacemaker cells. The Journal of physiology. 540 [PubMed]

Mills GD, Harris DM, Chen X, Houser SR. (2007). Intracellular sodium determines frequency-dependent alterations in contractility in hypertrophied feline ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 292 [PubMed]

Mitsuiye T, Guo J, Noma A. (1999). Nicardipine-sensitive Na+-mediated single channel currents in guinea-pig sinoatrial node pacemaker cells. The Journal of physiology. 521 Pt 1 [PubMed]

Moosmang S et al. (2001). Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. European journal of biochemistry. 268 [PubMed]

NOBLE D. (1962). A modification of the Hodgkin--Huxley equations applicable to Purkinje fibre action and pace-maker potentials. The Journal of physiology. 160 [PubMed]

Nikmaram MR et al. (2008). Characterization of the effects of ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes. Progress in biophysics and molecular biology. 96 [PubMed]

Ono K, Shibata S, Iijima T. (2003). Pacemaker mechanism of porcine sino-atrial node cells. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 39 [PubMed]

Oudit GY et al. (2001). The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium. Journal of molecular and cellular cardiology. 33 [PubMed]

Panzeri S, Ludtke N, Kharche S. (2009). A global sensitivity index for biophysically detailed cardiac cell models: a computational approach LNCS. 5528

Rose RA, Kabir MG, Backx PH. (2007). Altered heart rate and sinoatrial node function in mice lacking the cAMP regulator phosphoinositide 3-kinase-gamma. Circulation research. 101 [PubMed]

Sarai N, Matsuoka S, Kuratomi S, Ono K, Noma A. (2003). Role of individual ionic current systems in the SA node hypothesized by a model study. The Japanese journal of physiology. 53 [PubMed]

Satoh H. (2003). Sino-atrial nodal cells of mammalian hearts: ionic currents and gene expression of pacemaker ionic channels. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 39 [PubMed]

Shannon TR, Chu G, Kranias EG, Bers DM. (2001). Phospholamban decreases the energetic efficiency of the sarcoplasmic reticulum Ca pump. The Journal of biological chemistry. 276 [PubMed]

Shannon TR, Ginsburg KS, Bers DM. (2000). Reverse mode of the sarcoplasmic reticulum calcium pump and load-dependent cytosolic calcium decline in voltage-clamped cardiac ventricular myocytes. Biophysical journal. 78 [PubMed]

Shannon TR, Ginsburg KS, Bers DM. (2002). Quantitative assessment of the SR Ca2+ leak-load relationship. Circulation research. 91 [PubMed]

Shannon TR, Wang F, Bers DM. (2005). Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophysical journal. 89 [PubMed]

Shannon TR, Wang F, Puglisi J, Weber C, Bers DM. (2004). A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophysical journal. 87 [PubMed]

Shinagawa Y, Satoh H, Noma A. (2000). The sustained inward current and inward rectifier K+ current in pacemaker cells dissociated from rat sinoatrial node. The Journal of physiology. 523 Pt 3 [PubMed]

Sun H et al. (2008). Differential interactions of Na+ channel toxins with T-type Ca2+ channels. The Journal of general physiology. 132 [PubMed]

Tao T et al. (2008). Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study. American journal of physiology. Heart and circulatory physiology. 295 [PubMed]

Varghese A, Sell GR. (1997). A conservation principle and its effect on the formulation of Na-Ca exchanger current in cardiac cells. Journal of theoretical biology. 189 [PubMed]

Veldkamp MW et al. (2003). Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families. Circulation research. 92 [PubMed]

Verheijck EE, van Ginneken AC, Bourier J, Bouman LN. (1995). Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circulation research. 76 [PubMed]

Verheijck EE et al. (2001). Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution. Cardiovascular research. 52 [PubMed]

Verkerk AO et al. (2007). Single cells isolated from human sinoatrial node: action potentials and numerical reconstruction of pacemaker current. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2007 [PubMed]

Vinogradova TM et al. (2008). Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases. Circulation research. 102 [PubMed]

Wilders R. (2007). Computer modelling of the sinoatrial node. Medical & biological engineering & computing. 45 [PubMed]

Wu Y et al. (2009). Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Xu H, Guo W, Nerbonne JM. (1999). Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes. The Journal of general physiology. 113 [PubMed]

Xu H, Li H, Nerbonne JM. (1999). Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 alpha subunit. The Journal of physiology. 519 Pt 1 [PubMed]

Yin J et al. (2004). Effects of nanomolar concentration dihydroouabain on calcium current and intracellular calcium in guinea pig ventricular myocytes. Life sciences. 76 [PubMed]

Zhang H, Holden AV, Boyett MR. (2002). Sustained inward current and pacemaker activity of mammalian sinoatrial node. Journal of cardiovascular electrophysiology. 13 [PubMed]

Zhang H et al. (2000). Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. American journal of physiology. Heart and circulatory physiology. 279 [PubMed]

Zhang H et al. (2007). Computational evaluation of the roles of Na+ current, iNa, and cell death in cardiac pacemaking and driving. American journal of physiology. Heart and circulatory physiology. 292 [PubMed]

Zhang Z et al. (2002). Functional Roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circulation research. 90 [PubMed]

Zhou Z, Lipsius SL. (1994). T-type calcium current in latent pacemaker cells isolated from cat right atrium. Journal of molecular and cellular cardiology. 26 [PubMed]

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