A dynamic model of the canine ventricular myocyte (Hund, Rudy 2004)

The Hund-Rudy dynamic (HRd) model is based on data from the canine epicardial ventricular myocyte. Rate-dependent phenomena associated with ion channel kinetics, action potential properties and Ca2+ handling are simulated by the model. See paper for more and details.

Model Type: Neuron or other electrically excitable cell; Electrogenic pump

Cell Type(s): Heart cell; Cardiac ventricular cell

Currents: I Chloride; I Na,t; I K; I Calcium; Na/K pump

Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease; Sodium pump

Simulation Environment: MATLAB (web link to model); C or C++ program (web link to model)

Implementer(s): Decker, Keith [keithforestdecker at gmail.com]; Livshitz, Leonid [livshitz at wustl.edu]; Hund, Tom [thund at pathology.wustl.edu]


Hund TJ, Rudy Y. (2004). Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 110 [PubMed]

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