"A recent experimental study (Mizuseki et al., 2009) has shown that the temporal delays between population activities in successive entorhinal and hippocampal anatomical stages are longer (about 70–80 ms) than expected from axon conduction velocities and passive synaptic integration of feed-forward excitatory inputs. We investigate via computer simulations the mechanisms that give rise to such long temporal delays in the hippocampus structures. ... The model shows that the experimentally reported long temporal delays in the DG, CA3 and CA1 hippocampal regions are due to theta modulated somatic and axonic inhibition..."
Model Type: Realistic Network
Cell Type(s): Dentate gyrus granule GLU cell; Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell; Hippocampus CA1 basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA3 axo-axonic cells
Simulation Environment: NEURON
Implementer(s): Cutsuridis, Vassilis [vcutsuridis at gmail.com]
Cutsuridis V, Poirazi P. (2015). A computational study on how theta modulated inhibition can account for the long temporal windows in the entorhinal-hippocampal loop. Neurobiology of learning and memory. 120 [PubMed]