Axonal Projection and Interneuron Types (Helmstaedter et al. 2008)

"Interneurons in layer 2/3 (L2/3) of the somatosensory cortex show 4 types of axonal projection patterns with reference to the laminae and borders of columns in rat barrel cortex (Helmstaedter et al. 2008a). Here, we analyzed the dendritic geometry and electrical excitability of these interneurons. ... We conclude that 1) dendritic polarity is correlated to intrinsic electrical excitability, and 2) the axonal projection pattern represents an independent classifier of interneurons. "

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Currents: I Na,t; I L high threshold; I K; I M; I K,Ca

Model Concept(s): Influence of Dendritic Geometry

Simulation Environment: NEURON (web link to model)


Helmstaedter M, Sakmann B, Feldmeyer D. (2009). The relation between dendritic geometry, electrical excitability, and axonal projections of L2/3 interneurons in rat barrel cortex. Cerebral cortex (New York, N.Y. : 1991). 19 [PubMed]

Helmstaedter M, Sakmann B, Feldmeyer D. (2009). Neuronal correlates of local, lateral, and translaminar inhibition with reference to cortical columns. Cerebral cortex (New York, N.Y. : 1991). 19 [PubMed]

Helmstaedter M, Sakmann B, Feldmeyer D. (2009). L2/3 interneuron groups defined by multiparameter analysis of axonal projection, dendritic geometry, and electrical excitability. Cerebral cortex (New York, N.Y. : 1991). 19 [PubMed]

Helmstaedter M, Staiger JF, Sakmann B, Feldmeyer D. (2008). Efficient recruitment of layer 2/3 interneurons by layer 4 input in single columns of rat somatosensory cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

There are 3 other versions of this model. You may select a different one below:

View on GitHub
This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.