We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.
Region(s) or Organism(s): Striatum
Cell Type(s): Neostriatum spiny neuron
Genes: Cav3.2 CACNA1H
Simulation Environment: GENESIS
Implementer(s): Du, Kai [kai.du at ki.se]
Du K et al. (2017). Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proceedings of the National Academy of Sciences of the United States of America. 114 [PubMed]