Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)

We explored dendritic plateau potentials in a biophysically detailed SPN model. We coupled the dendritic plateaus to different types of inhibitions (dendritic fast and slow inhibitions, perisomatic inhibition from FS interneurons , etc.) We found the inhibition provides precise control over the plateau potential, and thus the spiking output of SPNs.

Model Type: Dendrite; Channel/Receptor

Region(s) or Organism(s): Striatum

Cell Type(s): Neostriatum spiny neuron

Currents: I A; I A, slow; Kir; I Calcium; I K,Ca; I L high threshold; I Na,p; I Na,t; I Q; I R; I K

Receptors: AMPA; GabaA; NMDA

Genes: Cav3.2 CACNA1H

Transmitters: Glutamate; Gaba

Simulation Environment: GENESIS

Implementer(s): Du, Kai [kai.du at ki.se]

References:

Du K et al. (2017). Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proceedings of the National Academy of Sciences of the United States of America. 114 [PubMed]