Based on the Layer 5 thick-tufted pyramidal cell from the Blue Brain Project, we modify the distribution of the sodium channel Nav1.2 to recapitulate an increase in excitability observed in ex vivo slice experiments.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Prefrontal cortex (PFC)
Cell Type(s): Neocortex layer 5 pyramidal cell
Genes: Nav1.2 SCN2A