Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al 2021)

Azouz R, Gray CM. (2000). Dynamic spike threshold reveals a mechanism for synaptic coincidence detection in cortical neurons in vivo. Proceedings of the National Academy of Sciences of the United States of America. 97 [PubMed]

Ben-Shalom R et al. (2017). Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures. Biological psychiatry. 82 [PubMed]

• Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017) [Model]

Bender KJ, Trussell LO. (2009). Axon initial segment Ca2+ channels influence action potential generation and timing. Neuron. 61 [PubMed]

Clarkson RL, Liptak AT, Gee SM, Sohal VS, Bender KJ. (2017). D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]

Erisir A, Lau D, Rudy B, Leonard CS. (1999). Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons. Journal of neurophysiology. 82 [PubMed]

Gazina EV et al. (2015). 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour. Human molecular genetics. 24 [PubMed]

Guan D, Tkatch T, Surmeier DJ, Armstrong WE, Foehring RC. (2007). Kv2 subunits underlie slowly inactivating potassium current in rat neocortical pyramidal neurons. The Journal of physiology. 581 [PubMed]

Hallermann S, de Kock CP, Stuart GJ, Kole MH. (2012). State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nature neuroscience. 15 [PubMed]

• State and location dependence of action potential metabolic cost (Hallermann et al., 2012) [Model]

Harnett MT, Xu NL, Magee JC, Williams SR. (2013). Potassium channels control the interaction between active dendritic integration compartments in layer 5 cortical pyramidal neurons. Neuron. 79 [PubMed]

Hay E, Hill S, Schürmann F, Markram H, Segev I. (2011). Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS computational biology. 7 [PubMed]

• L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011) [Model]
• Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018) [Model]
• Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017) [Model]

Howell KB et al. (2015). SCN2A encephalopathy: A major cause of epilepsy of infancy with migrating focal seizures. Neurology. 85 [PubMed]

Hu W et al. (2009). Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nature neuroscience. 12 [PubMed]

• Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009) [Model]

Kole MH, Letzkus JJ, Stuart GJ. (2007). Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. Neuron. 55 [PubMed]

Korngreen A, Sakmann B. (2000). Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients. The Journal of physiology. 525 Pt 3 [PubMed]

• Pyramidal Neuron Deep: K+ kinetics (Korngreen, Sakmann 2000) [Model]

Lau D et al. (2000). Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Li T et al. (2014). Action potential initiation in neocortical inhibitory interneurons. PLoS biology. 12 [PubMed]

Macica CM et al. (2003). Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Markram H et al. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell. 163 [PubMed]

• The neocortical microcircuit collaboration portal (Markram et al. 2015) [Model]

Ogiwara I et al. (2007). Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Planells-Cases R et al. (2000). Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Biophysical journal. 78 [PubMed]

Ramaswamy S, Markram H. (2015). Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron. Frontiers in cellular neuroscience. 9 [PubMed]

Spratt PWE et al. (2019). The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex. Neuron. 103 [PubMed]

Taddese A, Bean BP. (2002). Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron. 33 [PubMed]

Uebachs M, Schaub C, Perez-Reyes E, Beck H. (2006). T-type Ca2+ channels encode prior neuronal activity as modulated recovery rates. The Journal of physiology. 571 [PubMed]

Williams SR, Mitchell SJ. (2008). Direct measurement of somatic voltage clamp errors in central neurons. Nature neuroscience. 11 [PubMed]

Zagha E, Lang EJ, Rudy B. (2008). Kv3.3 channels at the Purkinje cell soma are necessary for generation of the classical complex spike waveform. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Barlow BSM, Longtin A, Joós B. (2024). Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment. PLoS computational biology. 20 [PubMed]

• Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment (Barlow et al., 2024) [Model]